Buffalo, New York
Grover Cleveland, 22nd and 24th President of the United States
Millard Fillmore, 13th President of the United States
Winifred C. Stanley, the first person to introduce equal pay legislation in the United States
Willis Carrier, inventor of modern air conditioning
Sidney Farber, considered the father of modern chemotherapy
Wilson Greatbatch, inventor of the Cardiac pacemaker
Charles E. Burchfield (1893–1967), watercolor painter
Adam Zyglis (1982-), editorial cartoonist
Scott Fitzgerald, novelist
Mark Twain, the pen name of Samuel Langhorne Clemens, iconic author
Ani DiFranco, singer, guitarist, multi-instrumentalist, poet, songwriter
Goo Goo Dolls, band
Rick James
Charles W. Goodyear
John J. Kennedy
Henry Wells
Disclaimer: These lists are just a few of the famous people who were born or called these cities home in the Rust Belt. Feel free to add your own in the comments. – Major Cities will post in alphabetical order.